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Sister Red Vol 1 by Shizuru Hayashiya. An Action manga rated Teen, published in English by Comics One in 2005.
Schoolgirl Mahito Takeda is struck down by a speeding car, then revived by Alice, a mysterious woman who tells her she has become a Median, a creature of the night. Granted half of an enchanted heart that brings immortality and the power to destroy other Medians, Mahito tries to hold on to her ordinary life while transforming into an avenger to face those responsible. But rival Median factions, far less kind than Alice, are already hunting her.